AL amyloidosis that presented with marked hepatomegaly and polyclonal hypergammaglobulinemia

Polyclonal plasma cell proliferation with marked hypergammaglobulinemia and multiple autoantibodies.

A 77-yr-old man presented with marked peripheral blood and bone marrow plasmacytosis, marked hypergammaglobulinemia, and multiple autoantibodies. Serum protein immunofixation and immunophenotyping of bone marrow plasma cells by flow cytometry and immunohistochemistry disclosed polyclonal proliferation of plasma cells at various stages of differentiation. The presence of multiple autoantibodies ...

Congenital neuroblastoma presented with cholestasis and huge hepatomegaly

This case report is about a 28-day-old neonate that had abdominal distention and massive hepatomegaly since 15th days of birth. First, he was normal, and he had not any sign and symptom of sepsis. At admission, he was about twelve days, he had a rapid progressive presentation of sepsis and unfortunately, he passed away. His liver biopsies manifested the neuroblastoma.

Multiple Myeloma with HBs Antigenemia Presented with Hoarseness and Systemic Amyloidosis

AL amyloidosis with renal involvement.

Primary (AL amyloidosis) is a systemic disease characterized by an amyloid deposition process in many organs, with unsatisfactory survival of patients. The monoclonal light chains form the fibrils that deposit and accumulate in tissues. Renal involvement is very frequent in AL amyloidosis and could lead to development of nephrotic syndrome followed by the renal failure in many cases. Classic th...

AL Amyloidosis

UNLABELLED DEFINITION OF THE DISEASE: AL amyloidosis results from extra-cellular deposition of fibril-forming monoclonal immunoglobulin (Ig) light chains (LC) (most commonly of lambda isotype) usually secreted by a small plasma cell clone. Most patients have evidence of isolated monoclonal gammopathy or smoldering myeloma, and the occurrence of AL amyloidosis in patients with symptomatic multip...